A study in The Journal of General Physiology examines the consequences of muscle activity with surprising results, indicating that the extracellular accumulation of potassium that occurs in working muscles is considerably higher than previously thought. Muscle excitation involves the influx of sodium ions and efflux of potassium ions. Although the fraction of ions that cross the muscle membrane with each contraction is minute, repeated activity can lead to substantial changes in the intracellular and extracellular concentrations of sodium and potassium ions...
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