The bacterium Pseudomonas aeruginosa needs iron to establish and maintain a biofilm in the lungs of cystic fibrosis patients, and therapies have been proposed to deprive the bacteria of this necessary element.
However, these techniques may not work, according to a new study published in mBio®...
The first randomised trial to investigate the treatment of low bone density in young people with cystic fibrosis (CF), published Online First in The Lancet Respiratory Medicine, provides compelling evidence that alendronate (a drug that curbs bone loss) is safe and can help increase bone mineral...
New research suggests that lowering excessive levels of a protein in immune system cells could be a strategy to clear an infection that is deadly to patients with cystic fibrosis (CF). Researchers determined that normalizing levels of the protein, called p62, in cells from mice carrying the most...
The first evidence of blood vessel dysfunction has been found in a small cohort of generally healthy young people with cystic fibrosis, researchers report. "Even though the lung function in these kids is fine at this point, there is evidence of vascular dysfunction and exercise intolerance,"...
Healthy people's lungs are home to a diverse community of microbes that differs markedly from the bacteria found in the lungs of cystic fibrosis patients. That's the result of new research from Stanford University and Lucile Packard Children's Hospital, which has wide implications for treatment...
A study published in the online journal Hepatology reports a potential new NADPH oxidase (NOX) inhibitor therapy for liver fibrosis, a scarring process associated with chronic liver disease that can lead to loss of liver function. "While numerous studies have now demonstrated that advanced liver...
University of North Carolina scientists have uncovered a new strategy that may one day help people with cystic fibrosis and chronic obstructive pulmonary disorder better clear the thick and sticky mucus that clogs their lungs and leads to life-threatening infections. In a new report appearing...
Researchers at the University of Pittsburgh School of Medicine have identified an agent that in lab tests protected the skin and lungs from fibrosis, a process that can ultimately end in organ failure and even death because the damaged tissue becomes scarred and can no longer function properly...
By developing software that uses 3-D models of proteins involved in cystic fibrosis, a team of scientists at Duke University has identified several new molecules that may ease the symptoms of the disease. Computer algorithms created by the team predict how well a given molecular structure will...
University of North Carolina at Chapel Hill researchers working as part of the International Cystic Fibrosis Consortium have discovered several regions of the genome that may predispose cystic fibrosis (CF) patients to develop an intestinal blockage while still in the uterus. A report of this...
Fibrosis is a harmful build-up of excessive fibrous tissue that results in scarring, and ultimately, the loss of organ function. Although it can affect any tissue and organ system, it is most common in the heart, liver, lung, peritoneum, and kidney. The fibrotic scar tissue consists of...
Results of the pivotal Phase 3 clinical trial published in the Nov. 3, 2011 New England Journal of Medicine, find that the oral medication ivacaftor (VX-770) provides major, sustained improvement in lung function, growth and other signs and symptoms for cystic fibrosis (CF) patients. The...
According to investigators at the University of Pittsburgh School of Medicine and Centocor R&D, a group of blood proteins can foresee which patients with idiopathic pulmonary fibrosis (IPF) - a progressive lung disease - are more likely to die within two years or live at least five years. The...
It's difficult for doctors to tell whether a patient with Crohn's disease has intestinal fibrosis, which requires surgery, or inflammation, which can be treated with medicine. A new imaging method might make that task easier, according to a U-M-led study. Ultrasound elasticity imaging, or UEI...
i have cystic fibrosis, sens i was 13 i smoked weed and ciggrits, and i stoped at the age 17 im about to be 18 june 23 and im doing my treatments now and taking my meds, and the doctors says my PFT are good, i dont understand i scwerd up that much of my life up and im still healthy, does anny...
My mom is in her mid-forties and has started feeling like her airway is closing ten years ago. This has gotten more severe and she has short breath on a regular basis. Sometimes she wakes up in the middle of the night because she has difficulties breathing. Is this cystic fibrosis?
Cystic fibrosis (CF) patients with normal to mildly impaired lung function may benefit from a new investigational drug designed to help prevent formation of the sticky mucus that is a hallmark of the disease, according to researchers involved in a phase 3 clinical trial of the drug. Called...
The Cystic Fibrosis Foundation announced that it will partner with CVS/pharmacy and Warner Home Video for the second year to raise critical funds for cystic fibrosis through the sale of classic family movies this holiday season. From now through Dec. 28, 2010, CVS/pharmacy will sell four...
Metabolon, Inc., the leader in global metabolomics, biomarker discovery and analysis, announces the publication of "Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells", in the Journal of Biological Chemistry (2010, Vol. 285...
Bonus: What is wrong with my body?
My eyes burn. My face feels swollen and sensitive. My gut feels bloated. The muscles over my chest are extremely sensitive to pain. My joints are sore. The middle of my back hurts so much when I sit that I cant's sit for more than a few minutes. MRI, X-Ray...