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Wilson, 32, has not missed a game since the 2008 season, a streak of 62 games that ranked among the five-longest among active NFL safeties. Incidentally, the Cardinals lost the game that Wilson missed by a score of 56-35.
Another surprise is that Denver Broncos running back Knowshon Moreno has been scratched. The former first-round pick fumbled in Monday night's loss to the Atlanta Falcons and will be replaced by rookie Ronnie Hillman, who will make his NFL debut on Sunday.
Philadelphia Eagles at Arizona Cardinals
Philadelphia: QB Trent Edwards, RB Dion Lewis, WR Jeremy Maclin, WR Riley Cooper, OT King Dunlap, OT Nate Menkin, DE Vinny Curry
Arizona: QB John Skelton, RB William Powell, WR LaRon Byrd, TE Todd Heap, OT Pat McQuistan, G Senio Kelemete, S Adrian Wilson
Atlanta Falcons at San Diego Chargers
Atlanta: QB Dominique Davis, RB Antone Smith, OL Joe Hawley, OT Lamar Holmes, DE Jonathan Massaquoi, DE Cliff Matthews, CB Christopher Owens
San Diego: RB Ronnie Brown, TE Ladarius Green, OT Jared Gaither, NT Antonio Garay, LB Jonas Mouton, CB Shareece Wright, S Brandon Taylor
Houston Texans at Denver Broncos
Houston: QB John Beck, WR DeVier Posey, OT Andrew Gardner, G Brandon Brooks, LB Tim Dobbins, CB Roc Carmichael, CB Brandon Harris
Denver: QB Caleb Hanie, RB Knowshon Moreno, WR Andre Caldwell, G Chris Kuper, G C.J. Davis, DT Sealver Siliga, LB Stevan Johnson
Pittsburgh Steelers at Oakland Raiders
Pittsburgh: QB Charlie Batch, RB Rashard Mendenhall, T Mike Adams, LB James Harrison, LB Stevenson Sylvester, LB Adrian Robinson, S Troy Polamalu
Oakland: QB Terrelle Pryor, WR Juron Criner, OT Khalif Barnes, OT Joe Barksdale, G Lucas Nix, DT Christo Bilukidi, CB Shawntae Spencer