You may think it might be the common mint flavor of toothpaste clashing with other flavors, but in the case of orange juice and many other things, this isn't actually what's going on. The culprit here is thought to be two compounds almost universally added to toothpastes -sodium lauryl sulfate and sodium lauryl ether sulfate, which are anionic surfactants, meaning they lower the surface tension of water.
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