When given for hours as a continuous dose, the heart medication nitroglycerin backfires - increasing the severity of subsequent heart attacks, according to a study of the compound in rats by researchers at the Stanford University School of Medicine. "Basically it's a cautionary tale," said professor of chemical and systems biology Daria Mochly-Rosen, PhD, senior author of the study that will be published Nov. 2 in Science Translational Medicine. "Here is a practice in medicine used for over 100 years. Nitroglycerin is so old that a proper clinical trial has never been formally done...
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