Mycobacterium tuberculosis, the bacterium that causes tuberculosis may have an Achilles' heel: It needs a particular enzyme to survive. Inhibiting that enzyme's function, researchers have shown, will kill the bacteria, pointing toward a design strategy for new TB drugs. To stay ahead in the race against drug-resistant infections, scientists constantly search for and exploit vulnerabilities in deadly bacteria. Now, researchers from Brown and the Massachusetts Institute of Technology have used a novel compound to exploit an Achilles' heel in the bacterium that causes tuberculosis...
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