Boston Children's Hospital has received Investigational New Drug (IND) approval from the US Food and Drug Administration (FDA) for neosaxitoxin, a new local anesthetic derived from cyanobacteria being developed in partnership with Proteus SA, of Santiago, Chile. With the IND approval in hand...
Oncopeptides AB, a company working to enhance oncology therapies, today announced that the first patient has been dosed as part of a Phase II study in multiple myeloma patients with its drug candidate melflufen (previously called J1). The trial is an open-label Phase II study designed to...
A new clinical research study at Roswell Park Cancer Institute (RPCI) will assess the safety and efficacy of a novel immunotherapy approach to treating advanced melanoma. Developed at RPCI by Roswell Park researchers, the investigational vaccine shows promise for treating tumors in patients with...
Seeking to improve the lives of sickle cell anemia sufferers around the world, researchers from the La Jolla Institute for Allergy and Immunology, the Dana-Farber/Children's Hospital Cancer Center in Boston and the BloodCenter of Wisconsin in Milwaukee and others are preparing to launch Phase II...
A potential gene therapy for Mucopolysaccharidosis Type IIIA Mucopolysaccharidosis Type IIIA (MPSIIIA) is a metabolic disorder in which the body is missing an enzyme that is required to break down long chains of sugars known as glycosaminoglycans. Over time, the glycosaminoglycans collect in the...
A detailed clinical description of two cases of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in France, published online in The Lancet today, suggests that the incubation period for the virus may be longer than previously thought, and longer quarantine periods may be required to rule...
Elsevier, a world-leading provider of scientific, technical and medical information products and services, has announced the publication of a clinical guide by the European Menopause and Andropause Society (EMAS) in the journal Maturitas on endometrial assessment in peri and postmenopausal women...
Certara™, a leading provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through drug development, announced that its Pharsight Consulting Services has developed a mathematical model of tumor growth inhibition, which when...
Researchers at Moffitt Cancer Center say identifying and selecting participants for phase II cancer clinical trials from a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and may speed test drugs through the drug...
An ACE in the hole for hypertension There are multiple environmental triggers that contribute to high blood pressure (hypertension), including aging, obesity, stress, alcohol intake, and excess dietary salt; however, the physiological mechanisms that are regulated by these triggers are not fully...
IDRI (Infectious Disease Research Institute), a Seattle-based non-profit research organization that is a leading developer of adjuvants used in vaccines combating infectious disease, and Medicago Inc. (TSX: MDG; OTCQX: MDCGF), a biopharmaceutical company focused on developing highly effective...
Research led by a biology professor in the School of Science at IUPUI has uncovered a method to produce retinal cells from regenerative human stem cells without the use of animal products, proteins or other foreign substances, which historically have limited the application of stem cells to...
The 13th annual European Clinical Data Forum is one of Arena International's flagship events, designed to meet the needs of those within clinical data management. The European Clinical Data Forum provides a unique format which allows delegates to tailor their own agenda according to their...
Phytopharm plc (PYM: London Stock Exchange) ("Phytopharm", the "Group" or the "Company") have announced the results of the Phase II, randomised, double blind, placebo controlled, dose-ranging trial of Cogane™ in unmedicated patients with early-stage Parkinson's disease ("CONFIDENT-PD"). Analysis...
Neurim Pharmaceuticals have announced positive results from a phase II clinical study evaluating the efficacy and safety of Piromelatine (Neu-P11), a novel investigational multimodal sleep medicine developed for the treatment of patients with primary and co-morbid insomnia. The new results are...
Clasado, the manufacturers and suppliers of Bimuno®, a unique trans-galactooligosaccharide prebiotic, have announced the results of a clinical study on the use of the Bimuno (B-GOS) to alter bacteria in the human gastrointestinal tract as a candidate to help prevent and manage Metabolic...
Cardiorentis has initiated the first-ever acute heart failure (AHF) Phase III trial to be specifically designed to assess the effect of early treatment on cardiovascular mortality. TRUE-AHF (TRial of Ularitide's Efficacy and safety in patients with Acute Heart Failure) aims to show that early...
Fox Chase Cancer Center, a National Cancer Institute-designated Comprehensive Cancer Center, is now offering patients with advanced cancer a cutting-edge clinical test that will provide them with a unique blueprint of their cancer genes. The new clinical test, known as CancerCode-45TM, evaluates...
An international study of ibrutinib in people with relapsed or refractory mantle cell lymphoma (MCL) continues to show unprecedented and durable results with few side effects. Researchers from The University of Texas MD Anderson Cancer Center presented interim findings of the multi-center Phase...
A recent University of Colorado Cancer Center review in the journal Advances in Nutrition shows that rice bran offers promising cancer prevention properties. Meanwhile, an ongoing clinical trial is testing the effectiveness of rice bran in preventing the recurrence of colon cancer. "While I have...