Last week, the rapidly evolving U.S. cannabis industry changed forever when one of the largest U.S. multi-state operators (MSOs), Trulieve Cannabis (OTC: TCNNF), agreed to acquire a smaller but still substantial peer, Harvest Health & Recreation (OTC: HRVSF), for .1 billion in stock. While most large U.S. MSOs have been scooping up smaller private companies and license holders in select states, this acquisition is the largest tie-up in U.S. cannabis history. It also occurs at a historic time, as the U.S. seems to have reached a tipping point regarding the legalization of cannabis across the country.