What anime or cartoon series should I watch?

What are some nice anime or cartoon series preferably with good mature humor(not stupid slapstick or plain stupid humor) has depth and if possible a good story(not nessessary for comedy). For anime I do like sexy anime ladies so bring it on but anything is fine. For cartoons I like the general stuff that people like, mainly because I dont look in too much on cartoons. Though adventure time is fun I dont usually watch it probably because of the animation so maybe a bit of weight there. I dont want to watch stuff just because they're generally popular but because they're actually good. I watched bleach a long time ago but I dont think it fits my taste anymore.

Animes that I still like
Hayate no Gotoku
Keroro Gunso
Samurai X
FMA
Death Note
Sun Flower Samurai(forgot the name but you know what im talking about)

Cartoons that I still like
My Little Pony(you heard me!)
Avatar