Mouse delay when gaming? HELP!!!!!?

I recently had a custom gaming computer built for myself. Whenever I am on the desktop and in other applications, the mouse responds with perfect timing (I have a 5ms gaming monitor). However, when I try to play Dead Space the mouse experiences a delay between the time I move my hand and the time the motion is demonstrated on the monitor. I'm not sure quite sure what the problem is. I have an extremely powerful gaming computer, so I'm not quite sure what the problem is. Could it be an issue with the mouse? Or some sort of driver? Help
I have 3 SLI GeForce GTX 780 Ti GPUs and 16 GB of Corsair Ram