Infiniti g35 or lexus is300?

It really depends on the generation and year. With that in mind, if you care about reliability and MPG more than straight line performance and looks, go with the Lexus. If you're more interested in the former, get the Infinti, but be prepared to bring it to the shop more often than the Lexus.
Hope that helps.

i like the g35 best. its the american skyline