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Well generally speaking, Diablo III should run on any Windows OS if that's what you're asking. But as for gameplay quality, that's completely different. That'll be dependant on the CPU usage of the game itself. Diablo III has been shown to have intensified its graphics, so that'll probably be a major conflict with average quality computers. But in the long run, you should be fine, as all Blizzard Releases should work on all Windows Systems.
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