Does anyone know who the longest survivor is with this variant of leukemia, or least those who have attained remission? Does it hurt very much towards the end stage, when it becomes more aggressive? How do you know if you're getting worse? How do you know if your doctors are right or wrong about the prognosis/outcome? Is there anyone who knows exactly what will happen? What if the person is doing mantainence therapy on rituxan, would it buy a little more time?

I'm sorry if my questions are really irritating, but what happens when it becomes refractory?