In many types of cancer, activated immune cells infiltrate the tumor and influence clinical outcome. It is not always clear where these cells are activated, but results reported in Cancer Research, a journal of the American Association for Cancer Research, indicate that in a subset of patients with metastatic melanoma, they can be activated in the tumor microenvironment. "Our data provide a new concept in melanoma," said Nicolas van Baren, M.D., Ph.D...

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