A systematic review of available evidence (low- to moderate-strength) did not find a link between statin use and adverse cognitive outcomes, according to a study published in Annals of Internal Medicine. Recently, the FDA issued a warning after case reports suggested that statin use may lead to cognitive impairment. Researchers reviewed 25 published randomized, controlled trials and cohort, case-control, and cross-sectional studies evaluating cognition inpatients taking statins.

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