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Italy's health ministry has recommended that people with a severely compromised immune system receive a fourth mRNA vaccine shot against COVID-19, provided that at least 120 days have passed from their previous booster, it said on Sunday. The ministry added that the decision reflects the still high circulation of the virus and the effectiveness that booster shots had shown in preventing COVID-related deaths and, more generally, symptoms that would require hospitalisation. Italy has registered 152,848 deaths linked to COVID-19 since its outbreak in February 2020, the second-highest toll in Europe behind Britain and the eighth highest in the world.