IvanTessmer
New member
- Oct 22, 2011
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I'm a 22 year old male. I started taking methadone on 4/3/11 a little over a month 05/18/11 they took some blood for testing and when the results got back they were pretty concerned about my AST ALT levels. They told me they were both about 3-5 times higher than normal and asked if i was an alcoholic. At the time i have been sober from alcohol for about 4-5 months but i used to get really intoxicated about 3-4 times a month for pretty much the whole year of 20010. Anyways, I asked what do high enzyme levels mean? and they didn't tell me anything but it could mean that i have liver damage but not to worry about it. This test was taken at the methadone clinic and they told me to follow up on it with my primary doctor.
It has been five months from the test and i still haven't seen a doctor because I'm absolutely terrified that its going to be something bad. I'm really frightened! I was looking on the internet and all i can see when searching about it is liver damage, disease and LIVER CANCER! AHHH So it is possible that i have liver cancer?
I weigh 180 and I'm 5'9 22 year old male. I take methadone. These are my levels.
AST (SGOT) H 252 IU/L (< 41)
ALT (SGPT) H 304 IU/L (< 46)
Those are my levels... I don't know what they mean. PLEASE do not write answers saying go see a doctor he will tell you. The reason i write this question is because i want to know what it means.
Does this mean they are damaged disease or cancer? Is this how they first test for liver cancer?
What would the doctor do if he tests me again and my levels are still high or increasing?
ALSO, I have read that methadone is a liver enzyme inhibitor. I do not know what that means but is it possible that methadone is the cause of the high enzymes? I have been blood tested a few times in my life and never have they said anything about high enzymes.
I read this but dont know what it means on wiki
It is metabolized by the enzymes CYP3A4, CYP2B6 and CYP2D6, with great variability between individuals
Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with a mean of around 22. However, metabolism rates vary greatly between individuals, up to a factor of 100,[46][47] ranging from as few as 4 hours to as many as 130 hours,[48] or even 190 hours.[49] This variability is apparently due to genetic variability in the production of the associated enzymes CYP3A4, CYP2B6 and CYP2D6. Many substances can also induce, inhibit or compete with these enzymes further affecting (sometimes dangerously) methadone half-life.
It has been five months from the test and i still haven't seen a doctor because I'm absolutely terrified that its going to be something bad. I'm really frightened! I was looking on the internet and all i can see when searching about it is liver damage, disease and LIVER CANCER! AHHH So it is possible that i have liver cancer?
I weigh 180 and I'm 5'9 22 year old male. I take methadone. These are my levels.
AST (SGOT) H 252 IU/L (< 41)
ALT (SGPT) H 304 IU/L (< 46)
Those are my levels... I don't know what they mean. PLEASE do not write answers saying go see a doctor he will tell you. The reason i write this question is because i want to know what it means.
Does this mean they are damaged disease or cancer? Is this how they first test for liver cancer?
What would the doctor do if he tests me again and my levels are still high or increasing?
ALSO, I have read that methadone is a liver enzyme inhibitor. I do not know what that means but is it possible that methadone is the cause of the high enzymes? I have been blood tested a few times in my life and never have they said anything about high enzymes.
I read this but dont know what it means on wiki
It is metabolized by the enzymes CYP3A4, CYP2B6 and CYP2D6, with great variability between individuals
Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with a mean of around 22. However, metabolism rates vary greatly between individuals, up to a factor of 100,[46][47] ranging from as few as 4 hours to as many as 130 hours,[48] or even 190 hours.[49] This variability is apparently due to genetic variability in the production of the associated enzymes CYP3A4, CYP2B6 and CYP2D6. Many substances can also induce, inhibit or compete with these enzymes further affecting (sometimes dangerously) methadone half-life.